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BDBM281101 US10022354, Example 41

SMILES: CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1cccc(C2CC2)c1=O

InChI Key: InChIKey=KCKPUNHLKNGJAR-CQSZACIVSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281101   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))		BDBM281101
PNG
(US10022354, Example 41)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1cccc(C2CC2)c1=O |r|
Show InChI InChI=1S/C19H24N4O2/c1-12(2)16-10-17(21-20-16)19(25)22-9-7-14(11-22)23-8-3-4-15(18(23)24)13-5-6-13/h3-4,8,10,12-14H,5-7,9,11H2,1-2H3,(H,20,21)/t14-/m1/s1
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0510n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...

US Patent US10022354 (2018)


BindingDB Entry DOI: 10.7270/Q2PC34F7
More data for this
Ligand-Target Pair