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SMILES: Oc1cccc2cc(ncc12)-n1ccc2ccncc12

InChI Key: InChIKey=AYXRYOIPOKGSSK-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281606   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))		BDBM281606
PNG
(US10022461, Compound 56)
Show SMILES Oc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-15-3-1-2-12-8-16(18-9-13(12)15)19-7-5-11-4-6-17-10-14(11)19/h1-10,20H
PDB

KEGG

UniProtKB/SwissProt

DrugBank
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PC cid
PC sid
UniChem
US Patent
 1.16 -12.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...

US Patent US10022461 (2018)


BindingDB Entry DOI: 10.7270/Q2959KK6
More data for this
Ligand-Target Pair