BDBM281622 US10022461, Compound 72

SMILES: CNc1cccc(c1)-c1ccc(nc1)-n1ccc2ccncc12

InChI Key: InChIKey=UJVPNGCHONKGFS-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281622   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM281622 (US10022461, Compound 72) Show SMILES CNc1cccc(c1)-c1ccc(nc1)-n1ccc2ccncc12 Show InChI InChI=1S/C19H16N4/c1-20-17-4-2-3-15(11-17)16-5-6-19(22-12-16)23-10-8-14-7-9-21-13-18(14)23/h2-13,20H,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.760	-12.4	n/a	n/a	n/a	n/a	n/a	7.4	25
Merck Sharp & Dohme Corp. US Patent					Assay Description For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...				US Patent US10022461 (2018) BindingDB Entry DOI: 10.7270/Q2959KK6
					More data for this Ligand-Target Pair