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SMILES: Nc1cc(I)cc2cnc(cc12)-n1ccc2ccncc12

InChI Key: InChIKey=LHSJAPAVBZXMOJ-UHFFFAOYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281657   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))		BDBM281657
PNG
(US10022461, Compound 127)
Show SMILES Nc1cc(I)cc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-12-5-11-8-20-16(7-13(11)14(18)6-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
 1.17 -12.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...

US Patent US10022461 (2018)


BindingDB Entry DOI: 10.7270/Q2959KK6
More data for this
Ligand-Target Pair