null
SMILES: NC(=O)c1cc(F)c(-c2cccc3CN(CCc23)C(=O)C=C)c2c3ccc(CCF)cc3[nH]c12
InChI Key: InChIKey=AZUKRIAOZXZCBL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM281758 (4-(2-acryloyl-1,2,3,4- tetrahydroisoquinolin- 5-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0290 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A... | US Patent US10023534 (2018) BindingDB Entry DOI: 10.7270/Q2WW7KQR | |||||||||||
More data for this Ligand-Target Pair |