BDBM28178 3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::BMCL191694 Compound 2::benzimidazole thiophene analogue, 29
SMILES: COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(s3)C(N)=O)c2cc1OC
InChI Key: InChIKey=WRWFZZDBIJLBIJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM28178 (3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,...) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.2 | 22 |
GSK | Assay Description The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-... | Bioorg Med Chem Lett 19: 1694-7 (2009) Article DOI: 10.1016/j.bmcl.2009.01.094 BindingDB Entry DOI: 10.7270/Q2319T6X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM28178 (3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,...) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.2 | 22 |
GSK | Assay Description The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-... | Bioorg Med Chem Lett 19: 1018-21 (2009) Article DOI: 10.1016/j.bmcl.2008.11.041 BindingDB Entry DOI: 10.7270/Q26T0JZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK3 (Homo sapiens (Human)) | BDBM28178 (3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,...) | PDB NCI pathway KEGG GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.2 | 22 |
GSK | Assay Description The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-... | Bioorg Med Chem Lett 19: 1694-7 (2009) Article DOI: 10.1016/j.bmcl.2009.01.094 BindingDB Entry DOI: 10.7270/Q2319T6X | |||||||||||
More data for this Ligand-Target Pair |