BDBM282831 6-(4-(3-chloro-4-fluorophenyl)-1-(3-hydroxypropyl)- 1H-imidaozl-5-yl)imidazo[1,2-b]pyridazine-3- carbonitrile::US10287295, Example 38'::US9884868, Example 38'

SMILES: OCCCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1

InChI Key: InChIKey=UHKKBSIHLQQAIZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 282831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282831 (6-(4-(3-chloro-4-fluorophenyl)-1-(3-hydroxypropyl)...) Show SMILES OCCCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H14ClFN6O/c20-14-8-12(2-3-15(14)21)18-19(26(11-24-18)6-1-7-28)16-4-5-17-23-10-13(9-22)27(17)25-16/h2-5,8,10-11,28H,1,6-7H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282831 (6-(4-(3-chloro-4-fluorophenyl)-1-(3-hydroxypropyl)...) Show SMILES OCCCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H14ClFN6O/c20-14-8-12(2-3-15(14)21)18-19(26(11-24-18)6-1-7-28)16-4-5-17-23-10-13(9-22)27(17)25-16/h2-5,8,10-11,28H,1,6-7H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM282831 (6-(4-(3-chloro-4-fluorophenyl)-1-(3-hydroxypropyl)...) Show SMILES OCCCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H14ClFN6O/c20-14-8-12(2-3-15(14)21)18-19(26(11-24-18)6-1-7-28)16-4-5-17-23-10-13(9-22)27(17)25-16/h2-5,8,10-11,28H,1,6-7H2	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282831 (6-(4-(3-chloro-4-fluorophenyl)-1-(3-hydroxypropyl)...) Show SMILES OCCCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H14ClFN6O/c20-14-8-12(2-3-15(14)21)18-19(26(11-24-18)6-1-7-28)16-4-5-17-23-10-13(9-22)27(17)25-16/h2-5,8,10-11,28H,1,6-7H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair