BDBM282858 (R)-6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluorocyclopentyl)-1H-imidazol-5-yl)imidazo[1,2- b]pyridazine-3-carbonitrile::US10287295, Example 63'::US9884868, Example 63'

SMILES: Fc1ccc(cc1Cl)-c1ncn([C@@H]2CCC(F)(F)C2)c1-c1ccc2ncc(C#N)n2n1

InChI Key: InChIKey=LUABADMUPNRBMU-CYBMUJFWSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 282858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282858 ((R)-6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluor...) Show SMILES Fc1ccc(cc1Cl)-c1ncn([C@@H]2CCC(F)(F)C2)c1-c1ccc2ncc(C#N)n2n1 |r| Show InChI InChI=1S/C21H14ClF3N6/c22-15-7-12(1-2-16(15)23)19-20(30(11-28-19)13-5-6-21(24,25)8-13)17-3-4-18-27-10-14(9-26)31(18)29-17/h1-4,7,10-11,13H,5-6,8H2/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282858 ((R)-6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluor...) Show SMILES Fc1ccc(cc1Cl)-c1ncn([C@@H]2CCC(F)(F)C2)c1-c1ccc2ncc(C#N)n2n1 |r| Show InChI InChI=1S/C21H14ClF3N6/c22-15-7-12(1-2-16(15)23)19-20(30(11-28-19)13-5-6-21(24,25)8-13)17-3-4-18-27-10-14(9-26)31(18)29-17/h1-4,7,10-11,13H,5-6,8H2/t13-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM282858 ((R)-6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluor...) Show SMILES Fc1ccc(cc1Cl)-c1ncn([C@@H]2CCC(F)(F)C2)c1-c1ccc2ncc(C#N)n2n1 |r| Show InChI InChI=1S/C21H14ClF3N6/c22-15-7-12(1-2-16(15)23)19-20(30(11-28-19)13-5-6-21(24,25)8-13)17-3-4-18-27-10-14(9-26)31(18)29-17/h1-4,7,10-11,13H,5-6,8H2/t13-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282858 ((R)-6-(4-(3-chloro-4-fluorophenyl)-1-(3,3- difluor...) Show SMILES Fc1ccc(cc1Cl)-c1ncn([C@@H]2CCC(F)(F)C2)c1-c1ccc2ncc(C#N)n2n1 |r| Show InChI InChI=1S/C21H14ClF3N6/c22-15-7-12(1-2-16(15)23)19-20(30(11-28-19)13-5-6-21(24,25)8-13)17-3-4-18-27-10-14(9-26)31(18)29-17/h1-4,7,10-11,13H,5-6,8H2/t13-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair