BDBM282953 6-(1-(cylcobutylmethyl)-4-(4-fluorophenyl)-1H- imidazol-5-yl)imidazo[1,2-a]pyridine-3-carboxamide::US10287295, Example 157'::US9884868, Example 157'

SMILES: NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC1CCC1)-c1ccc(F)cc1

InChI Key: InChIKey=NYRMMVHYJSKXFL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 282953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282953 (6-(1-(cylcobutylmethyl)-4-(4-fluorophenyl)-1H- imi...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC1CCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5O/c23-17-7-4-15(5-8-17)20-21(27(13-26-20)11-14-2-1-3-14)16-6-9-19-25-10-18(22(24)29)28(19)12-16/h4-10,12-14H,1-3,11H2,(H2,24,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282953 (6-(1-(cylcobutylmethyl)-4-(4-fluorophenyl)-1H- imi...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC1CCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5O/c23-17-7-4-15(5-8-17)20-21(27(13-26-20)11-14-2-1-3-14)16-6-9-19-25-10-18(22(24)29)28(19)12-16/h4-10,12-14H,1-3,11H2,(H2,24,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM282953 (6-(1-(cylcobutylmethyl)-4-(4-fluorophenyl)-1H- imi...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC1CCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5O/c23-17-7-4-15(5-8-17)20-21(27(13-26-20)11-14-2-1-3-14)16-6-9-19-25-10-18(22(24)29)28(19)12-16/h4-10,12-14H,1-3,11H2,(H2,24,29)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282953 (6-(1-(cylcobutylmethyl)-4-(4-fluorophenyl)-1H- imi...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC1CCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5O/c23-17-7-4-15(5-8-17)20-21(27(13-26-20)11-14-2-1-3-14)16-6-9-19-25-10-18(22(24)29)28(19)12-16/h4-10,12-14H,1-3,11H2,(H2,24,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair