BDBM283015 5-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazin-3-yl)oxazole::US10287295, Example 216'::US9884868, Example 216'

SMILES: FC(F)Cn1cnc(c1-c1ccc2ncc(-c3cnco3)n2n1)-c1ccc(F)cc1

InChI Key: InChIKey=FFARGLZRLVWCLR-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 283015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283015 (5-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(-c3cnco3)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H13F3N6O/c21-13-3-1-12(2-4-13)19-20(28(10-26-19)9-17(22)23)14-5-6-18-25-7-15(29(18)27-14)16-8-24-11-30-16/h1-8,10-11,17H,9H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM283015 (5-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(-c3cnco3)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H13F3N6O/c21-13-3-1-12(2-4-13)19-20(28(10-26-19)9-17(22)23)14-5-6-18-25-7-15(29(18)27-14)16-8-24-11-30-16/h1-8,10-11,17H,9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM283015 (5-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(-c3cnco3)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H13F3N6O/c21-13-3-1-12(2-4-13)19-20(28(10-26-19)9-17(22)23)14-5-6-18-25-7-15(29(18)27-14)16-8-24-11-30-16/h1-8,10-11,17H,9H2	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM283015 (5-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(-c3cnco3)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H13F3N6O/c21-13-3-1-12(2-4-13)19-20(28(10-26-19)9-17(22)23)14-5-6-18-25-7-15(29(18)27-14)16-8-24-11-30-16/h1-8,10-11,17H,9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair