BDBM283184 N-[1-{N′-cyano-N-[3-(difluoromethoxy)-5-fluorophenyl]carbamimidoyl}-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide Isomer 1::US10023539, Example 24.1::US10023539, Example 24.2
SMILES: CCN(C1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cc(F)cc(OC(F)F)c1)=N/C#N)C(=O)CO
InChI Key: InChIKey=GOXPTBFRMOWJPX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N-lysine methyltransferase SMYD2 (Homo sapiens (Human)) | BDBM283184 (N-[1-{N′-cyano-N-[3-(difluoromethoxy)-5-fluo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19.2 | n/a | n/a | n/a | n/a | 9.0 | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea... | US Patent US10023539 (2018) BindingDB Entry DOI: 10.7270/Q2MG7RKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-lysine methyltransferase SMYD2 (Homo sapiens (Human)) | BDBM283184 (N-[1-{N′-cyano-N-[3-(difluoromethoxy)-5-fluo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | 9.0 | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea... | US Patent US10023539 (2018) BindingDB Entry DOI: 10.7270/Q2MG7RKD | |||||||||||
More data for this Ligand-Target Pair |