BDBM283516 4'-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7- yl)-3'-fluoro-N-[(1R)-2-hydroxy-1- methylethyl]biphenyl-2-sulfonamide::US9745328, Compound 390::US9884878, Compound 390
SMILES: C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1
InChI Key: InChIKey=DSODKTGYNFIXOL-CQSZACIVSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-lipoxygenase/FLAP (Homo sapiens (Human)) | BDBM283516 (4'-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7- yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... | US Patent US9884878 (2018) BindingDB Entry DOI: 10.7270/Q2R78H8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM283516 (4'-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7- yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... | US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446 | |||||||||||
More data for this Ligand-Target Pair |