BDBM283535 N-((1-amino-5-methylisoquinolion-6-yl)methyl)- 2-((3-(trifluoromethyl)quinolin-6- yl)methyl)isonicotinamide::US10023557, Example 184::US10308637, Example 184
SMILES: Cc1c(CNC(=O)c2ccnc(Cc3ccc4ncc(cc4c3)C(F)(F)F)c2)ccc2c(N)nccc12
InChI Key: InChIKey=ZNCHUSONBPLTLN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasma kallikrein (Homo sapiens (Human)) | BDBM283535 (N-((1-amino-5-methylisoquinolion-6-yl)methyl)- 2-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.5 | n/a |
LIFESCI PHARMACEUTICALS, INC. US Patent | Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ... | US Patent US10023557 (2018) BindingDB Entry DOI: 10.7270/Q2BZ6839 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM283535 (N-((1-amino-5-methylisoquinolion-6-yl)methyl)- 2-(...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals | Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ... | Bioorg Med Chem Lett 19: 3541-5 (2009) BindingDB Entry DOI: 10.7270/Q25141K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM283535 (N-((1-amino-5-methylisoquinolion-6-yl)methyl)- 2-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
LIFESCI PHARMACEUTICALS, INC. US Patent | Assay Description The test compounds at various concentrations, also prepared by serial dilutions as described above, are added to the test wells. The volume of test c... | US Patent US10023557 (2018) BindingDB Entry DOI: 10.7270/Q2BZ6839 | |||||||||||
More data for this Ligand-Target Pair |