BindingDB PrimarySearch

BDBM28393 (+)-EHNA::(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol::CHEMBL296435

SMILES: CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12

InChI Key: InChIKey=IOSAAWHGJUZBOG-WDEREUQCSA-N

Data: 9 KI 15 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 28393
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	0.820	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Rhode Island Curated by ChEMBL					Assay Description Tested for binding affinity against calf intestinal Adenosine Deaminase (ADA)				J Med Chem 37: 3844-9 (1994) BindingDB Entry DOI: 10.7270/Q2FT8K2W
University of Rhode Island Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against adenosine deaminase in calf intestinal mucosa.				Bioorg Med Chem Lett 6: 2417-2420 (1996) Article DOI: 10.1016/0960-894X(96)00439-8 BindingDB Entry DOI: 10.7270/Q2PK0G3T
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	1.13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Rhode Island Curated by ChEMBL					Assay Description Inhibition of Adenosine deaminase (ADA) of calf intestine				J Med Chem 43: 4694-700 (2001) BindingDB Entry DOI: 10.7270/Q2KD1ZM2
University of Rhode Island Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	1.14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibitory constant against bovine spleen Adenosine deaminase				J Med Chem 48: 5162-74 (2005) Article DOI: 10.1021/jm050136d BindingDB Entry DOI: 10.7270/Q2542PCH
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of adenosine deaminase				J Med Chem 24: 1383-5 (1982) BindingDB Entry DOI: 10.7270/Q22N52T8
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Rhode Island Curated by ChEMBL					Assay Description Compound was evaluated for inhibition of calf intestinal mucosa adenosine deaminase (ADA)				Bioorg Med Chem Lett 8: 1639-42 (1999) BindingDB Entry DOI: 10.7270/Q2M044JJ
University of Rhode Island Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Rhode Island Curated by ChEMBL					Assay Description Binding affinity (Ki) at calf intestinal Adenosine deaminase				J Med Chem 35: 4180-4 (1992) Checked by Author BindingDB Entry DOI: 10.7270/Q2SQ9118
University of Rhode Island Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Advinus Therapeutics Ltd. Curated by ChEMBL					Assay Description Inhibition of bovine adenosine deaminase pre-incubated for 5 mins before adenosine addition				Bioorg Med Chem 25: 5799-5819 (2017) Article DOI: 10.1016/j.bmc.2017.09.015 BindingDB Entry DOI: 10.7270/Q2M0482X
Advinus Therapeutics Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenosine deaminase (Bos taurus (bovine))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	1.14E+3	-8.24	n/a	n/a	n/a	n/a	n/a	7.2	30
Universita di Pisa					Assay Description The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...				J Med Chem 52: 1681-92 (2009) Article DOI: 10.1021/jm801427r BindingDB Entry DOI: 10.7270/Q29K48J8
Universita di Pisa					More data for this Ligand-Target Pair				3D Structure (crystal)
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	635	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE2 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4A by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE8B by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4B by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE10 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 9A (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE9 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE8A by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE3 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 11A (PDE11A) (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE11 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE5 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE1 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE2A catalytic domain (580 to 919 residues) expressed in Escherichia coli BL21 (Codonplus) using [3H]cGMP as substra...				Bioorg Med Chem 26: 119-133 (2018) Article DOI: 10.1016/j.bmc.2017.11.022 BindingDB Entry DOI: 10.7270/Q26D5WKW
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Changzhou University Curated by ChEMBL					Assay Description Inhibition of human PDE2 using c[8-3H]cAMP or c[8-3H]cGMP as substrate measured after 10 mins by liquid scintillation counting method				Bioorg Med Chem Lett 29: 481-486 (2019) Article DOI: 10.1016/j.bmcl.2018.12.018
Changzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4D by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1 (Homo sapiens (Human))	BDBM28393 ((+)-EHNA \| (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4C by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair