BDBM28395 (2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phenyl)prop-2-enoic acid::pyrazine inhibitor, 15

SMILES: NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1

InChI Key: InChIKey=KCXFEPOPVGRWEO-VOTSOKGWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM28395 ((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...) Show SMILES NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1 Show InChI InChI=1S/C17H20N4O2/c18-8-1-2-9-20-16-12-19-11-15(21-16)14-5-3-4-13(10-14)6-7-17(22)23/h3-7,10-12H,1-2,8-9,18H2,(H,20,21)(H,22,23)/b7-6+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	22
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...				J Med Chem 52: 1814-27 (2009) Article DOI: 10.1021/jm801242y BindingDB Entry DOI: 10.7270/Q25T3HS3
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM28395 ((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...) Show SMILES NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1 Show InChI InChI=1S/C17H20N4O2/c18-8-1-2-9-20-16-12-19-11-15(21-16)14-5-3-4-13(10-14)6-7-17(22)23/h3-7,10-12H,1-2,8-9,18H2,(H,20,21)(H,22,23)/b7-6+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	7.5	22
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...				J Med Chem 52: 1814-27 (2009) Article DOI: 10.1021/jm801242y BindingDB Entry DOI: 10.7270/Q25T3HS3
					More data for this Ligand-Target Pair