BDBM284871 7-(2-(piperazin-1-yl)pyridin-4-yl)-5- (1-(tetrahydro-2H-pyran-4-yl)-1H- pyrazol-5-yl)pyrrolo[2,1-f][1,2,4] triazin-4-amine::US10023576, Example 62

SMILES: Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccnc(c1)N1CCNCC1

InChI Key: InChIKey=SUNZXKAHFMNGTP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM284871 (7-(2-(piperazin-1-yl)pyridin-4-yl)-5- (1-(tetrahyd...) Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C23H27N9O/c24-23-22-18(19-2-6-28-31(19)17-3-11-33-12-4-17)14-20(32(22)29-15-27-23)16-1-5-26-21(13-16)30-9-7-25-8-10-30/h1-2,5-6,13-15,17,25H,3-4,7-12H2,(H2,24,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assay				Bioorg Med Chem Lett 27: 855-861 (2017) BindingDB Entry DOI: 10.7270/Q2BR8VFH
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM284871 (7-(2-(piperazin-1-yl)pyridin-4-yl)-5- (1-(tetrahyd...) Show SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C23H27N9O/c24-23-22-18(19-2-6-28-31(19)17-3-11-33-12-4-17)14-20(32(22)29-15-27-23)16-1-5-26-21(13-16)30-9-7-25-8-10-30/h1-2,5-6,13-15,17,25H,3-4,7-12H2,(H2,24,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	25
Bristol-Myers Squibb Company US Patent					Assay Description The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...				US Patent US10023576 (2018) BindingDB Entry DOI: 10.7270/Q2FQ9ZND
					More data for this Ligand-Target Pair