BDBM285517 5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)pyrazolo[1,5-a]pyridine-3-carboxamide (racemate)::US10077265, Example 4::US10077265, Example 5

SMILES: COCCC(C(=O)Nc1ccn2ncc(C(N)=O)c2c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N

InChI Key: InChIKey=OCRCHYZWRKVQCQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285517   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM285517 (5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...) Show SMILES COCCC(C(=O)Nc1ccn2ncc(C(N)=O)c2c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N Show InChI InChI=1S/C26H23ClN6O5/c1-37-8-6-21(26(36)31-17-5-7-33-22(10-17)20(13-30-33)25(29)35)32-14-23(38-2)19(11-24(32)34)18-9-16(27)4-3-15(18)12-28/h3-5,7,9-11,13-14,21H,6,8H2,1-2H3,(H2,29,35)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...				US Patent US10077265 (2018) BindingDB Entry DOI: 10.7270/Q2XS5XFT
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM285517 (5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...) Show SMILES COCCC(C(=O)Nc1ccn2ncc(C(N)=O)c2c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N Show InChI InChI=1S/C26H23ClN6O5/c1-37-8-6-21(26(36)31-17-5-7-33-22(10-17)20(13-30-33)25(29)35)32-14-23(38-2)19(11-24(32)34)18-9-16(27)4-3-15(18)12-28/h3-5,7,9-11,13-14,21H,6,8H2,1-2H3,(H2,29,35)(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the reac...				US Patent US10077265 (2018) BindingDB Entry DOI: 10.7270/Q2XS5XFT
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM285517 (5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...) Show SMILES COCCC(C(=O)Nc1ccn2ncc(C(N)=O)c2c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N Show InChI InChI=1S/C26H23ClN6O5/c1-37-8-6-21(26(36)31-17-5-7-33-22(10-17)20(13-30-33)25(29)35)32-14-23(38-2)19(11-24(32)34)18-9-16(27)4-3-15(18)12-28/h3-5,7,9-11,13-14,21H,6,8H2,1-2H3,(H2,29,35)(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the reac...				US Patent US10077265 (2018) BindingDB Entry DOI: 10.7270/Q2XS5XFT
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM285517 (5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...) Show SMILES COCCC(C(=O)Nc1ccn2ncc(C(N)=O)c2c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N Show InChI InChI=1S/C26H23ClN6O5/c1-37-8-6-21(26(36)31-17-5-7-33-22(10-17)20(13-30-33)25(29)35)32-14-23(38-2)19(11-24(32)34)18-9-16(27)4-3-15(18)12-28/h3-5,7,9-11,13-14,21H,6,8H2,1-2H3,(H2,29,35)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	7.4	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...				US Patent US10077265 (2018) BindingDB Entry DOI: 10.7270/Q2XS5XFT
					More data for this Ligand-Target Pair