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BDBM285535 Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imidazo[1,2-b]pyridazin-2-yl]methanone (8)::US10077269, Example 8

SMILES: O=C(N1CCC1)c1nc2cccnn2c1-c1ccc2ccnn2c1

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285535   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285535
PNG
(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Show SMILES O=C(N1CCC1)c1nc2cccnn2c1-c1ccc2ccnn2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 20n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285535
PNG
(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Show SMILES O=C(N1CCC1)c1nc2cccnn2c1-c1ccc2ccnn2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5.44E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285535
PNG
(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Show SMILES O=C(N1CCC1)c1nc2cccnn2c1-c1ccc2ccnn2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 64.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285535
PNG
(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Show SMILES O=C(N1CCC1)c1nc2cccnn2c1-c1ccc2ccnn2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 41.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair