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BDBM285566 3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 39::US9598421, Example 39

SMILES: O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1

InChI Key:

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 285566   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 14.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 26.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 67.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.82E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 14.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 26.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 67.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.82E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair