new BindingDB logo
myBDB logout

BDBM285567 3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 40::US9598421, Example 40

SMILES: Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1

InChI Key:

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 285567   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 19.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 65.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 58.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 9.02E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 19.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 65.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 58.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 9.02E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair