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BDBM285571 3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopro-pyl)imidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 44::US9598421, Example 44

SMILES: Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285571   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285571
PNG
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.92n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285571
PNG
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 320n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285571
PNG
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.92n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285571
PNG
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 320n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair