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BDBM285579 US10077269, Example 52::US9598421, Example 52::azetidin-1-yl[3-(4-chloro-2-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]methanone

SMILES: Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1

InChI Key:

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 285579   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 24.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 37.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 113n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5.51E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 24.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 37.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 113n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


Article DOI: 10.1021/jm030933g
BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285579
PNG
(US10077269, Example 52 | US9598421, Example 52 | a...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5.51E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair