null
SMILES: CNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
InChI Key: InChIKey=XVPMLCYXSAROSC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... | US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... | US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... | US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... | US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD... | US Patent US9598421 (2017) BindingDB Entry DOI: 10.7270/Q2K939KG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v... | US Patent US10669279 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | US Patent US9598421 (2017) BindingDB Entry DOI: 10.7270/Q2K939KG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | US Patent US9598421 (2017) BindingDB Entry DOI: 10.7270/Q2K939KG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v... | US Patent US10669279 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v... | US Patent US10669279 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v... | US Patent US10669279 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM285624 (3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | US Patent US9598421 (2017) BindingDB Entry DOI: 10.7270/Q2K939KG | ||||||||||||
More data for this Ligand-Target Pair |