BDBM28574 1-sulfonylindazole, 6c::3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]propanamide

SMILES: NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12

InChI Key: InChIKey=YSQAQADMLFUOTE-UHFFFAOYSA-N

Data: 8 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 28574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	-12.6	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	155	-9.19	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+3	>-7.69	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+3	>-7.69	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+3	>-7.69	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+3	>-7.69	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	5.10E+3	-7.14	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	6.40E+3	-7.01	n/a	n/a	n/a	n/a	n/a	7.4	22
Wyeth Research					Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...				Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF
					More data for this Ligand-Target Pair