BDBM28574 1-sulfonylindazole, 6c::3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]propanamide
SMILES: NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
InChI Key: InChIKey=YSQAQADMLFUOTE-UHFFFAOYSA-N
Data: 8 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -12.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 155 | -9.19 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+3 | >-7.69 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+3 | >-7.69 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+3 | >-7.69 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+3 | >-7.69 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 5.10E+3 | -7.14 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 6.40E+3 | -7.01 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair |