BDBM285811 US10080744, Example 15

SMILES: C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCC2)-c2cccc(CC(C)(C)OC=O)c2)c(Cl)c1Cl)C(F)(F)F

InChI Key: InChIKey=CUVZGVHOVNOXFM-INIZCTEOSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285811   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM285811 (US10080744, Example 15) Show SMILES C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCC2)-c2cccc(CC(C)(C)OC=O)c2)c(Cl)c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C28H29Cl2F3N2O4S2/c1-16(28(31,32)33)35-41(37,38)22-11-10-20(23(29)24(22)30)25-21(13-17-6-4-7-17)34-26(40-25)19-9-5-8-18(12-19)14-27(2,3)39-15-36/h5,8-12,15-17,35H,4,6-7,13-14H2,1-3H3/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...				US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM285811 (US10080744, Example 15) Show SMILES C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCC2)-c2cccc(CC(C)(C)OC=O)c2)c(Cl)c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C28H29Cl2F3N2O4S2/c1-16(28(31,32)33)35-41(37,38)22-11-10-20(23(29)24(22)30)25-21(13-17-6-4-7-17)34-26(40-25)19-9-5-8-18(12-19)14-27(2,3)39-15-36/h5,8-12,15-17,35H,4,6-7,13-14H2,1-3H3/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...				US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM
					More data for this Ligand-Target Pair