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SMILES: O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O

InChI Key: InChIKey=WZAZBGHAPRDLFW-BWZBUEFSSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285838   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM285838 ((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...) Show SMILES O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O |r| Show InChI InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.90	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Alectos Therapeutics Inc. US Patent					Assay Description Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...				US Patent US10081601 (2018) BindingDB Entry DOI: 10.7270/Q2S184JZ
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM285838 ((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...) Show SMILES O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O |r| Show InChI InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc. US Patent					Assay Description Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...				US Patent US9796680 (2017) BindingDB Entry DOI: 10.7270/Q2SN0C36
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM285838 ((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...) Show SMILES O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O |r| Show InChI InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc. US Patent					Assay Description Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...				US Patent US9796680 (2017) BindingDB Entry DOI: 10.7270/Q2SN0C36
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM285838 ((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...) Show SMILES O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O |r| Show InChI InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.0	n/a
Alectos Therapeutics Inc. US Patent					Assay Description Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...				US Patent US10081601 (2018) BindingDB Entry DOI: 10.7270/Q2S184JZ
					More data for this Ligand-Target Pair