BDBM285873 (S)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-7-hydroxy-7-(5-(4-((methoxycarbonyl)amino)phenyl)-1H-imidazol-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-1-oxide and (R)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-7-hydroxy-7-(5-(4-((methoxycarbonyl)amino)phenyl)-1H-imidazol-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-1-oxide::US10081617, Example 21

SMILES: COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@]1(O)CCc2cc(c[n+]([O-])c12)-c1cc(Cl)ccc1-n1cnnn1

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM285873 ((S)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-7-hydr...) Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@]1(O)CCc2cc(c[n+]([O-])c12)-c1cc(Cl)ccc1-n1cnnn1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...				US Patent US10081617 (2018) BindingDB Entry DOI: 10.7270/Q2CR5WDN
					More data for this Ligand-Target Pair