BDBM286034 2-(Difluoromethyl)-N-(1-ethyl-2-(4-(trifluoromethyl)phenyl)-1H-indol-5-yl)-5-(((2-fluoro-2-methyl-propanoyl)amino)methyl)nicotinamide::US10081629, Example 17

SMILES: CCn1ccc2cc(NC(=O)c3cc(CNC(=O)C(C)(C)F)cnc3C(F)F)ccc12

InChI Key: InChIKey=YMVXSCTWGKRLNS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM286034 (2-(Difluoromethyl)-N-(1-ethyl-2-(4-(trifluoromethy...) Show SMILES CCn1ccc2cc(NC(=O)c3cc(CNC(=O)C(C)(C)F)cnc3C(F)F)ccc12 Show InChI InChI=1S/C22H23F3N4O2/c1-4-29-8-7-14-10-15(5-6-17(14)29)28-20(30)16-9-13(11-26-18(16)19(23)24)12-27-21(31)22(2,3)25/h5-11,19H,4,12H2,1-3H3,(H,27,31)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent					Assay Description mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...				US Patent US10081629 (2018) BindingDB Entry DOI: 10.7270/Q20K2BMF
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM286034 (2-(Difluoromethyl)-N-(1-ethyl-2-(4-(trifluoromethy...) Show SMILES CCn1ccc2cc(NC(=O)c3cc(CNC(=O)C(C)(C)F)cnc3C(F)F)ccc12 Show InChI InChI=1S/C22H23F3N4O2/c1-4-29-8-7-14-10-15(5-6-17(14)29)28-20(30)16-9-13(11-26-18(16)19(23)24)12-27-21(31)22(2,3)25/h5-11,19H,4,12H2,1-3H3,(H,27,31)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.68	n/a	n/a	n/a	n/a	n/a	n/a
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent					Assay Description mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...				US Patent US10081629 (2018) BindingDB Entry DOI: 10.7270/Q20K2BMF
					More data for this Ligand-Target Pair