BDBM286069 2-Chloro-N-(3-oxo-2-(4-(trifluoromethyl)phenyl)isoindolin-5-yl)-5-((2,2-dimethyl-propanoyl)amino)methyl)-benzamide::US10081629, Example 58
SMILES: CC(C)(C)C(=O)NCc1ccc(Cl)c(c1)C(=O)Nc1ccc2CN(C(=O)c2c1)c1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=HZRWITHIRLKVAT-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM286069 (2-Chloro-N-(3-oxo-2-(4-(trifluoromethyl)phenyl)iso...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent | Assay Description mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each... | US Patent US10081629 (2018) BindingDB Entry DOI: 10.7270/Q20K2BMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E synthase (Homo sapiens (Human)) | BDBM286069 (2-Chloro-N-(3-oxo-2-(4-(trifluoromethyl)phenyl)iso...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent | Assay Description mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each... | US Patent US10081629 (2018) BindingDB Entry DOI: 10.7270/Q20K2BMF | |||||||||||
More data for this Ligand-Target Pair |