BDBM2862 3-(5-bromopyridin-2-yl)-1-[3-(2-fluorophenyl)-3-oxopropyl]thiourea::PETT deriv. 12
SMILES: Fc1ccccc1C(=O)CCNC(=S)Nc1ccc(Br)cn1
InChI Key: InChIKey=OLZLESUYMWMOIH-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2862 (3-(5-bromopyridin-2-yl)-1-[3-(2-fluorophenyl)-3-ox...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.8 | 37 |
Medivir AB | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | Bioorg Med Chem Lett 10: 265-8 (2000) Article DOI: 10.1016/s0960-894x(99)00675-7 BindingDB Entry DOI: 10.7270/Q2DF6PDR | |||||||||||
More data for this Ligand-Target Pair |