BDBM286267 N-(2-ethyl-5-fluoropyrimidin-4-yl)-6,6-dimethyl-5-{[(2S)-2,4,5,5-tetramethylpiperazin-1-yl]carbonyl}-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine::US9518060, Example D1
SMILES: CCc1ccc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)N(C)C[C@@H]2C)C3(C)C)n1
InChI Key: InChIKey=NASWGROEELAJMP-AWEZNQCLSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human)) | BDBM286267 (N-(2-ethyl-5-fluoropyrimidin-4-yl)-6,6-dimethyl-5-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.43 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
PFIZER INC. US Patent | Assay Description Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe... | US Patent US9518060 (2016) BindingDB Entry DOI: 10.7270/Q2ZK5JPN | |||||||||||
More data for this Ligand-Target Pair |