BDBM286310 N-(5-fluoro-2-propylpyrimidin-4-yl)-6,6-dimethyl-5-{[(2S)-2,4,5,5-tetramethylpiperazin-1-yl]carbonyl}-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine::US9518060, Example I1

SMILES: C.CCCc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)NC[C@@H]2C)C3(C)C)n1

InChI Key: InChIKey=HCVHDJCKBSUQEW-ZOWNYOTGSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 286310   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM286310 (N-(5-fluoro-2-propylpyrimidin-4-yl)-6,6-dimethyl-5...) Show SMILES C.CCCc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)NC[C@@H]2C)C3(C)C)n1 |r| Show InChI InChI=1S/C22H33FN8O.CH4/c1-7-8-16-24-10-15(23)19(26-16)27-18-14-11-31(22(5,6)17(14)28-29-18)20(32)30-12-21(3,4)25-9-13(30)2;/h10,13,25H,7-9,11-12H2,1-6H3,(H2,24,26,27,28,29);1H4/t13-;/m0./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.73	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
PFIZER INC. US Patent					Assay Description Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...				US Patent US9518060 (2016) BindingDB Entry DOI: 10.7270/Q2ZK5JPN
					More data for this Ligand-Target Pair