BDBM286380 N-(4-ethoxypyrimidin-2-yl)-6,6-dimethyl-5-{[(2S,5R)-2,4,5-trimethylpiperazin-1-yl]carbonyl}-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine::US9518060, Example M1

SMILES: CCOc1ccnc(Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)n1

InChI Key: InChIKey=VFPDTTYPIIITKQ-KGLIPLIRSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286380   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C beta type (Homo sapiens (Human))	BDBM286380 (N-(4-ethoxypyrimidin-2-yl)-6,6-dimethyl-5-{[(2S,5R...) Show SMILES CCOc1ccnc(Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)n1 |r| Show InChI InChI=1S/C21H32N8O2/c1-7-31-16-8-9-22-19(23-16)24-18-15-12-29(21(4,5)17(15)25-26-18)20(30)28-11-13(2)27(6)10-14(28)3/h8-9,13-14H,7,10-12H2,1-6H3,(H2,22,23,24,25,26)/t13-,14+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		4.24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Homo sapiens (Human))	BDBM286380 (N-(4-ethoxypyrimidin-2-yl)-6,6-dimethyl-5-{[(2S,5R...) Show SMILES CCOc1ccnc(Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)n1 |r| Show InChI InChI=1S/C21H32N8O2/c1-7-31-16-8-9-22-19(23-16)24-18-15-12-29(21(4,5)17(15)25-26-18)20(30)28-11-13(2)27(6)10-14(28)3/h8-9,13-14H,7,10-12H2,1-6H3,(H2,22,23,24,25,26)/t13-,14+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.24	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
PFIZER INC. US Patent					Assay Description Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...				US Patent US9518060 (2016) BindingDB Entry DOI: 10.7270/Q2ZK5JPN
					More data for this Ligand-Target Pair