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BDBM286467 2-Methoxy-6-(6-methoxy-4-((3-(5-(1-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)pyridin-2-yl)benzyl)oxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole::US9518064, Example 86

SMILES: COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)OC3CCCCO3)cc(OC)cc2o1

InChI Key: InChIKey=QQJQTHCXCDSIRW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 286467   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM286467
PNG
(2-Methoxy-6-(6-methoxy-4-((3-(5-(1-((tetrahydro-2H...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)OC3CCCCO3)cc(OC)cc2o1
Show InChI InChI=1S/C33H32N4O6S/c1-20(42-31-9-4-5-12-40-31)23-10-11-26(34-17-23)22-8-6-7-21(13-22)19-41-28-14-24(38-2)15-29-25(28)16-30(43-29)27-18-37-32(35-27)44-33(36-37)39-3/h6-8,10-11,13-18,20,31H,4-5,9,12,19H2,1-3H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.560n/an/an/an/an/a25



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...

US Patent US9518064 (2016)


BindingDB Entry DOI: 10.7270/Q2TT4SZX
More data for this
Ligand-Target Pair