BDBM287884 8-(1-methyl-1H-pyrazol-5- yl)-6-(6,7,8,9-tetrahydro- 5H-benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10086000, Example 101::US10508108, Example 101
SMILES: Cn1nccc1-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1
InChI Key: InChIKey=UGPNXLIHHNDMRR-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IDH1 R132H (Homo sapiens (Human)) | BDBM287884 (8-(1-methyl-1H-pyrazol-5- yl)-6-(6,7,8,9-tetrahydr...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp... | US Patent US10508108 (2019) BindingDB Entry DOI: 10.7270/Q2N018X9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
IDH1 R132H (Homo sapiens (Human)) | BDBM287884 (8-(1-methyl-1H-pyrazol-5- yl)-6-(6,7,8,9-tetrahydr...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp... | US Patent US10086000 (2018) BindingDB Entry DOI: 10.7270/Q2N58PCG | |||||||||||
More data for this Ligand-Target Pair |