BDBM288189 5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-(trifluoromethyl)-::US10087185, Example 7

SMILES: FC(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F

InChI Key: InChIKey=WKQVDOSUICZWNI-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288189 (5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-...) Show SMILES FC(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)12-8(15(19,20)21)1-2-10-23-14(13(17)18)25-26(10)12/h1-5,13H,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair