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SMILES: FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F

InChI Key: InChIKey=OITIUWGXSUAAHK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288198   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM288198
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...)
Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)12-8(13(17)18)1-2-10-23-14(15(19,20)21)25-26(10)12/h1-5,13H,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...

US Patent US10087185 (2018)


BindingDB Entry DOI: 10.7270/Q2QZ2D0H
More data for this
Ligand-Target Pair