BDBM288248 5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl)-7-::US10087185, Example 66

SMILES: FC(F)(F)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F

InChI Key: InChIKey=FRIMHQHGVUTXLQ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288248 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C17H8ClF6N3O/c18-11-4-8(3-7-5-13(28)25-14(7)11)15-10(16(19,20)21)2-1-9-6-12(17(22,23)24)26-27(9)15/h1-4,6H,5H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair