BDBM288250 5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl)-7-::US10087185, Example 68

SMILES: FC(F)(F)c1ccc2cc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1

InChI Key: InChIKey=SQPORFMPQGZUQH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288250 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1 Show InChI InChI=1S/C19H13ClF3N3O/c20-14-6-11(5-10-7-16(27)24-17(10)14)18-13(19(21,22)23)4-3-12-8-15(9-1-2-9)25-26(12)18/h3-6,8-9H,1-2,7H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair