BDBM288252 7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-::US10087185, Example 118::US10087185, Example 70

SMILES: FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1

InChI Key: InChIKey=DNPCBZFAEFGRCH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 288252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288252 (7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4/c19-14-6-10(5-11-8-23-24-16(11)14)17-13(18(20,21)22)4-3-12-7-15(9-1-2-9)25-26(12)17/h3-9H,1-2H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288252 (7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4/c19-14-6-10(5-11-8-23-24-16(11)14)17-13(18(20,21)22)4-3-12-7-15(9-1-2-9)25-26(12)17/h3-9H,1-2H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair