BDBM288260 5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-methyl-::US10087185, Example 78

SMILES: Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F

InChI Key: InChIKey=RGSHYTRIWVSUFU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288260   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288260 (5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-...) Show SMILES Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-6-2-9(16(20,21)22)12(27-15(6)24-14(26-27)13(18)19)7-3-8-5-23-25-11(8)10(17)4-7/h2-5,13H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair