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SMILES: Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F

InChI Key: InChIKey=MSYUAECNFRJNAV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288303   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM288303
PNG
(6-(Difluoromethyl)-7-(7-methyl-1H-indazol-5-yl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C17H11F5N4/c1-8-4-9(5-10-7-23-24-14(8)10)15-12(16(18)19)3-2-11-6-13(17(20,21)22)25-26(11)15/h2-7,16H,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0250n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...

US Patent US10087185 (2018)


BindingDB Entry DOI: 10.7270/Q2QZ2D0H
More data for this
Ligand-Target Pair