BDBM288527 (1R,3R,5S,6r)-3-[8- amino-1-(2-ethoxy-4- {[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]bicyclo[3.1.0] hexane-6-carboxylic acid::US10087188, Example 135

SMILES: CCOc1cc(ccc1-c1nc([C@H]2C[C@H]3[C@@H](C2)[C@@H]3C(O)=O)n2ccnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key: InChIKey=FEOJBYAAHMWGTQ-DNEIQLIYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM288527 ((1R,3R,5S,6r)-3-[8- amino-1-(2-ethoxy-4- {[4- (tri...) Show SMILES CCOc1cc(ccc1-c1nc([C@H]2C[C@H]3[C@@H](C2)[C@@H]3C(O)=O)n2ccnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F |r| Show InChI InChI=1S/C28H25F3N6O4/c1-2-41-19-11-13(26(38)35-20-12-15(5-6-33-20)28(29,30)31)3-4-16(19)22-23-24(32)34-7-8-37(23)25(36-22)14-9-17-18(10-14)21(17)27(39)40/h3-8,11-12,14,17-18,21H,2,9-10H2,1H3,(H2,32,34)(H,39,40)(H,33,35,38)/t14-,17-,18+,21+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...				US Patent US10087188 (2018) BindingDB Entry DOI: 10.7270/Q2GF0WJC
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