BDBM28961 CHEMBL180641::ethyl 4-[(4-chlorobenzene)sulfonyl]-4-phenylpiperidine-1-carboxylate::phenylpiperidine-1-carboxylate, 1
SMILES: CCOC(=O)N1CCC(CC1)(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1
InChI Key: InChIKey=IZUORZWWEJPTQV-UHFFFAOYSA-N
Data: 3 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Gamma-Secretase (Homo sapiens (Human)) | BDBM28961 (CHEMBL180641 | ethyl 4-[(4-chlorobenzene)sulfonyl]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... | Bioorg Med Chem Lett 18: 4232-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM28961 (CHEMBL180641 | ethyl 4-[(4-chlorobenzene)sulfonyl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA | Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM28961 (CHEMBL180641 | ethyl 4-[(4-chlorobenzene)sulfonyl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description In vitro effective concentration against beta amyloid protein 42 in ELISA | Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 | |||||||||||
More data for this Ligand-Target Pair |