BDBM28985 N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl}propane-1-sulfonamide::cyclohexyl sulfone-based compound, 31
SMILES: CCCS(=O)(=O)N[C@H]1CC[C@@](CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1
InChI Key: InChIKey=ZWLPKHQJSKIALO-UEDWGHLCSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Gamma-Secretase (Homo sapiens (Human)) | BDBM28985 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.820 | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr... | Bioorg Med Chem Lett 16: 280-4 (2006) Article DOI: 10.1016/j.bmcl.2005.10.009 BindingDB Entry DOI: 10.7270/Q22Z13VQ | |||||||||||
More data for this Ligand-Target Pair |