BDBM290292 2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b]indazole-10-carbonitrile trifluoroacetate::US10098883, Example 33::US10098883, Example 53::US10668071, Example 53
SMILES: O=c1cc(C2CCNCC2)n2nc3cccc(C#N)c3c2[nH]1
InChI Key: InChIKey=VARWJCCPAVWDOP-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen (aa 101-181) (Homo sapiens (Human)) | BDBM290292 (2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall... | US Patent US10098883 (2018) BindingDB Entry DOI: 10.7270/Q2G73GSM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (aa 101-181) (Homo sapiens (Human)) | BDBM290292 (2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel... | US Patent US10668071 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (aa 101-181) (Homo sapiens (Human)) | BDBM290292 (2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel... | US Patent US10668071 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (aa 101-181) (Homo sapiens (Human)) | BDBM290292 (2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall... | US Patent US10098883 (2018) BindingDB Entry DOI: 10.7270/Q2G73GSM | |||||||||||
More data for this Ligand-Target Pair |