BDBM290314 10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2(1H)-one hydrochloride::US10098883, Example 57::US10098883, Example 95::US10668071, Example 95

SMILES: Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1

InChI Key: InChIKey=VPTAHBAWJZYJEI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 290314   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (aa 101-181) (Homo sapiens (Human))	BDBM290314 (10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...) Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1 Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.0	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...				US Patent US10098883 (2018) BindingDB Entry DOI: 10.7270/Q2G73GSM
					More data for this Ligand-Target Pair
Plasminogen (aa 101-181) (Homo sapiens (Human))	BDBM290314 (10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...) Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1 Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...				US Patent US10668071 (2020)
					More data for this Ligand-Target Pair
Plasminogen (aa 101-181) (Homo sapiens (Human))	BDBM290314 (10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...) Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1 Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...				US Patent US10668071 (2020)
					More data for this Ligand-Target Pair
Plasminogen (aa 101-181) (Homo sapiens (Human))	BDBM290314 (10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...) Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1 Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.0	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...				US Patent US10098883 (2018) BindingDB Entry DOI: 10.7270/Q2G73GSM
					More data for this Ligand-Target Pair