BDBM290389 5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyrrolidin-1- yl)nicotinic acid::US10098902, Example 25::US10603330, Example 25

SMILES: N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O

InChI Key: InChIKey=GHFICTSVEXRMAL-GWCFXTLKSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 290389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arginase-1 (Homo sapiens (Human))	BDBM290389 (5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...) Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O |r| Show InChI InChI=1S/C13H20BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h2,4,6-7,10,20-21H,1,3,5,8-9,15H2,(H,18,19)/t10-,13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290389 (5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...) Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O |r| Show InChI InChI=1S/C13H20BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h2,4,6-7,10,20-21H,1,3,5,8-9,15H2,(H,18,19)/t10-,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020)
					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290389 (5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...) Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O |r| Show InChI InChI=1S/C13H20BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h2,4,6-7,10,20-21H,1,3,5,8-9,15H2,(H,18,19)/t10-,13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020)
					More data for this Ligand-Target Pair
Arginase-2, mitochondrial (Homo sapiens (Human))	BDBM290389 (5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...) Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O |r| Show InChI InChI=1S/C13H20BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h2,4,6-7,10,20-21H,1,3,5,8-9,15H2,(H,18,19)/t10-,13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
					More data for this Ligand-Target Pair