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BDBM290407 (3R,4S)-3-amino-4-(3-boronopropyl)-1-((S)-pyrrolidine-2- carbonyl)pyrrolidine-3-carboxylic acid::US10098902, Example 43::US10603330, Example 43

SMILES: N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1CCCN1)C(O)=O

InChI Key: InChIKey=OHNHSUQVNXSZCH-DZGIZQBRSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 290407   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-1


(Homo sapiens (Human))
BDBM290407
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((S)-pyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1CCCN1)C(O)=O |r|
Show InChI InChI=1S/C13H24BN3O5/c15-13(12(19)20)8-17(11(18)10-4-2-6-16-10)7-9(13)3-1-5-14(21)22/h9-10,16,21-22H,1-8,15H2,(H,19,20)/t9-,10?,13-/m0/s1
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)


BindingDB Entry DOI: 10.7270/Q2319XXK
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290407
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((S)-pyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1CCCN1)C(O)=O |r|
Show InChI InChI=1S/C13H24BN3O5/c15-13(12(19)20)8-17(11(18)10-4-2-6-16-10)7-9(13)3-1-5-14(21)22/h9-10,16,21-22H,1-8,15H2,(H,19,20)/t9-,10?,13-/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10603330 (2020)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens (Human))
BDBM290407
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((S)-pyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1CCCN1)C(O)=O |r|
Show InChI InChI=1S/C13H24BN3O5/c15-13(12(19)20)8-17(11(18)10-4-2-6-16-10)7-9(13)3-1-5-14(21)22/h9-10,16,21-22H,1-8,15H2,(H,19,20)/t9-,10?,13-/m0/s1
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10603330 (2020)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290407
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((S)-pyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1CCCN1)C(O)=O |r|
Show InChI InChI=1S/C13H24BN3O5/c15-13(12(19)20)8-17(11(18)10-4-2-6-16-10)7-9(13)3-1-5-14(21)22/h9-10,16,21-22H,1-8,15H2,(H,19,20)/t9-,10?,13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)


BindingDB Entry DOI: 10.7270/Q2319XXK
More data for this
Ligand-Target Pair