BDBM290819 (S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-amino-3-methoxypropan-2-ylamino)pyrimidine-5-carboxamide::US9579320, Example 219

SMILES: COC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1

InChI Key: InChIKey=JAKQXGYHHPARGR-LBPRGKRZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 290819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM290819 ((S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-...) Show SMILES COC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1 |r| Show InChI InChI=1S/C17H21N9O2/c1-28-10-12(8-18)24-17-20-9-14(15(19)27)16(25-17)23-11-3-2-4-13(7-11)26-21-5-6-22-26/h2-7,9,12H,8,10,18H2,1H3,(H2,19,27)(H2,20,23,24,25)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
Portola Pharmaceuticals, Inc. US Patent					Assay Description Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...				US Patent US9579320 (2017) BindingDB Entry DOI: 10.7270/Q2K07692
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM290819 ((S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-...) Show SMILES COC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1 |r| Show InChI InChI=1S/C17H21N9O2/c1-28-10-12(8-18)24-17-20-9-14(15(19)27)16(25-17)23-11-3-2-4-13(7-11)26-21-5-6-22-26/h2-7,9,12H,8,10,18H2,1H3,(H2,19,27)(H2,20,23,24,25)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	7.5	25
Portola Pharmaceuticals, Inc. US Patent					Assay Description Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...				US Patent US9579320 (2017) BindingDB Entry DOI: 10.7270/Q2K07692
					More data for this Ligand-Target Pair